Categories
brain disease conflict resolution DSM mental disorders Mental Illness pathologizing

Are Mental Illnesses Really Genetic Diseases?

depressed-manAt 39-years of age, Ron had been a respected employee in a department store for nearly ten years. If he had made it to ten full years, he would have qualified for some extra benefits. Upper management chose to replace him with someone new a week before the ten years were up. Discovering that landing a new job was leading to one rejection after another, Ron fell into an anguishing depression.
 
Observing him having sleepless nights and losing weight, Ron’s wife urged him to see a mental health professional. concerned-woman“You’ve been paying for mental health coverage on your health policy for over fifteen years. You might as well take advantage of it and see if a professional can help you through this.”
 
Ron resisted, but when he received yet another terribly anxiety producing employment rejection, tears streamed down like two little waterfalls.
 
freud-smoking-cigarAt his first appointment with Dr. Sigmund, a cigar smoking psychologist, Ron discovered that to access mental health services with his health policy, he would have to be labeled as a person with a mental disorder. “I don’t want that kind of nonsense in my medical record,” he told Dr. Sigmund. “I’m not mentally ill! I’m just going through some tough times right now and I can use some professional help getting through this.”
 
“After a long drag on his cigar, Dr. Sigmund sadly explained, “I have to place on the insurance form a mental disorder diagnosis or I can’t see you.” 
 
Thoughts began to race through Ron’s head. Sometimes, on a job application form it asks if I had ever been treated for a mental disorder. If I answer truthfully, that could end up costing me the job. If I lie and someone broke into the insurance records system and released them to the public, I could be convicted of fraud. I was thinking of some day going into politics. If anyone ever got wind of the fact that I was given a so called mental disorder diagnosis, that could be the end of that.
 
health-insurance-form“Listen, Doctor, I’ve been paying for this mental health coverage for years and no one ever told me I had to be given a stigmatizing label to access services. That’s not fair.”
 
“You feel it’s unfair,” said Dr. Freud. He then paused, frowned, and said, “I’m sorry, but that’s how the system works. And, after all, these are real disorders, based on sound science. genes-4In fact we have recently learned that these disorders are properly viewed as genetic diseases. The evidence is pretty plain. We have learned that these types of conditions run in families, and genetic research has even identified the actual genes that are involved.”
 
Upon hearing this, Ron chose to walk out of the doctor’s office feeling more miserable than when he arrived.
In the above parable, Dr. Sigmund makes three statements.
  1. “I have to place on the insurance form a mental disorder diagnosis or I can’t see you.”
  2. these [mental disorders] are real disorders, based on sound science.”
  3. these disorders are properly viewed as genetic diseases.”
I have discussed extensively in earlier posts the issues surrounding the first two statements, so I’ll just briefly address them in the next section while providing the links to those earlier posts. Then we’ll go into a more in-depth discussion about the third statement which declares that mental disorders are properly viewed as genetic diseases.

Dr. Sigmund’s First Two Statements

health-insurance-companies-logos-insurance-logosFirst, Dr. Sigmund declares that “Without a mental disorder diagnosis, which I must place on the insurance form, I can’t see you.” This is pretty often true. In the United States, if you want to take advantage of your mental health insurance coverage, insurers require a mental disorder diagnosis [see HERE]. Some mental health service providers will see paying customers without the necessity of labeling if the customer pays the entire cost for the services. Paying for services that are not at least partly covered by insurance typically are too costly for the average Joe or Jill.
The second statement made by Dr. Sigmund is, “these are real disorders, based on sound science.” scienceIn my opinion, it is not sound science that came up with these types of labels, but rather, a business model that serves the pharmaceutical industry and psychiatry. Psychologists have gone along with the plan for practical reasons. Additionally, some actually are convinced that the labeling system is indeed based on principles of science. For a full critique of their position, see HERE.
In my view, the various conditions that get classified as mental disorders are more aptly construed as concerns about the following group of topics: behavior, emotion, mood, addictions, meaning of life, death, dying, managing chronic pain, work, interpersonal relationships, intrapersonal relationships, education, eating, cognition, sleep, and challenging life situation. This group of concerns, for the purpose of accessing mental health services would, under my proposal, be called “mental health concerns.” The concerns, rather than a person, would be classified for insurance purposes. Emphasis would be made on the fact that individuality outruns any classification system.

The Third Statement by Dr. Sigmund

genes-3In the parable, Dr. Sigmund declares that “these disorders are properly viewed as genetic diseases.” Is this a fair statement? The simple answer is no. To reasonably arrive at this answer, we’ll have to spend some time going step by step through some basic ideas.

Dr. Sigmund provides two general statements as a defense for his declaration–“We have learned that these types of conditions run in families, and genetic research has even identified the actual genes that are involved.”

When psychologists say that a certain set of characteristics that is classifiable as a mental disorder runs in the family, it doesn’t mean that if someone in the family has that set of characteristics, everyone in the family will have the same set of characteristics. identical-twinsEven identical twins won’t always have the same set of these types of characteristics despite the fact that a pair of identical twins have the same set of genes.

What psychologists typically mean by saying a set of characteristics run in the family, is that there is evidence that there is an increased probability that if one member of the family has the set, other family members are more likely to also have that set. Should this type of evidence lead us to conclude that such a set indicates the presence of a genetic disease?

characteristics-dogTo understand why the answer is no, we have to first understand that all species have a great number of characteristics, and each of their characteristics vary to some extent between different members of their species. For example, human beings have a typical height, they can run at a typical speed, etc. The average height of male humans is about 5 feet, 9 inches. Some, men are, however, somewhat taller, others are somewhat shorter, and some are quite a bit taller or quite a bit shorter. Similarly, some men can run at the average speed for men, while others can run at various rates that are different from average.

tallshortIf someone is above average in height, this does not mean he or she will be above average in running speed. Each of our numerous characteristics can be either within the average range, above average, or below, and because someone is below average in some set of characteristics does not mean that he or she will not have some characteristics that are average or even above average. And these differences are a great boom to the human race. If everyone was brilliant in academics and also had a strong genetic desire to be a professor at Ivy League universities, who would build the roads, drive our trucks, grow our crops, serve in law enforcement, cut our hair, tend to the sick, serve as fire fighters, staff stores, serve us in restaurants, etc.? People with different interests and talents enhance our own lives.

Now, clearly some human characteristics do run in the family. How tall you become is one such characteristic. Nevertheless, even if both of your parents are taller than average, you may still end up shorter than average.

characteristics-2If you do end up shorter than average this does not mean you have a genetic disease, even if we can demonstrate that taller people tend to have some advantages over people who are shorter. Saying that people who are shorter than average have a dysfunction would be stigmatizing while clouding the fact that we cannot determine a person’s overall functioning based on just one set of characteristics. Being shorter, when combined with the rest of a person’s characteristics, can lead to him or her being more useful in a variety of ways.

athletics_at_the_2008_summer_paralympics_-_mens_1500_metres_t13Let’s move on now from discussing a person’s height to a more complex set of characteristics–athletic performance. There is some evidence that athletic performance might be a set of characteristics that, to some degree, runs in the family. Deliberate practice seems to be a much greater predictor of skill in a particular sport, but let’s say for argument sake that at least to some extent there is indeed some inheritability to this set of characteristics. If a physical education teacher sees a child performing below average in athletic achievement, even if we are completely confident that this characteristic runs in the family, does this mean that this child has a genetic disease?

We could, if we wanted, label the child as having a “Muscle Deficit Disorder,” and claim that he or she rightfully has a genetic disease which is treatable with steroids. That would not, in my opinion, be in the child’s best interest. Admittedly that is just my value judgment. But I also contend that if we wanted to label the child as having a “Muscle Deficit Disorder,” that too would be a decision based on a value judgment, rather than one based on being consistent with principles of science.

physical-edRather than pathologizing below average athletic skills, I’ve seen physical education teachers who encourage such children to participate in some after school programs that develop skills in sports that can be practiced non-competitively, such as running, bicycling, and golf. Some of these children take to such programs willingly and end up staying in fine physical shape the rest of their lives. If they don’t, they suffer the consequences and all of us end up paying higher health premiums because they are at an increased risk of getting sick. At the same time, their other sets of characteristics, when combined with their couch potato ways, may offer them and the rest of us some valued fruits.

Just because some people have a different group of genes that might increase the likelihood that a certain set of characteristics will be expressed does not mean these people have a disease. dysfunction-junctionI know that some psychologists say, it is only the sets of characteristics that can be linked in some way to a “dysfunction” that are properly labeled as a disease. But the dysfunctional descriptor is so vague that it can be applied to the vast majority of people, and, perhaps, everyone.

Let’s say we can identify a set of genes that increase the chances that someone will enlist in the military. Now, let’s say we find that joining the military places these people at greater risk of harm, and even death. Would the finding of this type of connection require us to say that this means all who join the military have a dysfunction and therefore they also have a genetic disease? How about people who have become addicted to smoking, like old Dr. Sigmund? At one point, most Americans were smoking. Smoking can be labeled a dysfunctional characteristic. If it tends to run in the family, would that justify our declaring that all of this majority had a genetic disease?

psychiatristHow about becoming a psychiatrist? This may run in the family. If we find that becoming a psychiatrist increases the likelihood of committing suicide, which some data suggests, are all of them to be viewed as having a genetic disease, or would it be clearer, and more scientific, to say their set of characteristics is a “risk factor” for some negative outcome? I believe the latter is more scientific.

How about just being a male? Being a male increases the risk of violence. Or how about being a woman? Being a woman increases a person’s risk of becoming depressed, which psychopathologists are eager to tell us is a dysfunction. Don’t these facts pretty much indict us all with regards to having a genetic disease?

Now let’s turn to the statement that genetic research has identified the actual genes that are involved in mental disorders. I have read this research carefully and came away convinced that we are not even close to making this claim. Evaluating the research is complicated, but I’ll just make two simple points about this that can help readers to better understand this issue.

First of all, if Dr. Sigmund’s statement was true, mental disorders would be diagnosed by doing a test of one’s genes. This is not how mental disorder diagnoses are made. conversationInstead, psychologists have a conversation with the person seeking mental health services.

Second, if genes determined whether or not someone had a particular set of characteristics that gets labeled a mental disorder, what happens to those genes when someone who was labeled as having a mental disorder recovers, which often occurs? Do the genes somehow float out of the person’s body, and rise up to heaven? Actually the genes in the body remain right where they were when the person was said to have a mental disorder.

flowers_budsAs I read the research on this issue, it became plain to see that genes can be likened to the buds of a beautiful flower. If they meet up with the right soil, sunlight, water, and care, they typically blossom into something beautiful. But even with a great deal of wonderful nourishment, sometimes they get tangled up with some surrounding weeds. Stigmatizing labels don’t help in such situations. Instead, some wise gardening can make a beautiful difference.

——————————-

Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.

Categories
brain disease conflict resolution DSM mental disorders Mental Illness psychiatrists psychiatry psychologists psychopathology The Diagnostic and Statistical Manual of Mental Disorders

Are Mental Illnesses Really Brain Diseases?

Dr Eric Kandel
Dr Eric Kandel

In an article titled “The Roots of Mental Illness,” the author, Kirsten Weir, tells us about Eric Kandel, MD, who believes that the experiences that doctors refer to as mental illnesses are brain diseases. Dr. Kandel defends his belief with the following statement: “All mental processes are brain processes, and therefore all disorders of mental functioning are biological diseases. The brain is the organ of the mind.”

The article also indicates that Dr. Kandel believes one important value of recognizing that these types of experiences are brain diseases is that it helps minimize the shame often associated with them. For example, Dr. Kandel is quoted as saying, “Schizophrenia is a disease like pneumonia. Seeing it as a brain disorder destigmatizes it immediately.”

kandel-nobel-prizeDr. Kandel’s credentials are pretty impressive–he’s a Nobel Prize laureate and professor of brain science at Columbia University. Therefore, if you are among those who believe a person’s credentials should determine who is right and who is wrong, you need not read any further. You must simply conclude that what is referred to as mental illnesses are indeed brain diseases because you would be hard pressed to find someone with better credentials disagreeing with Dr. Kandel.

However, if you are among those of us who believe that regardless of someone’s credentials, the reasonableness of the argument should sway your judgments, then I encourage you to read on. In brief, you will find that the phrase, “disorders of mental functioning” is way too vague for a science of disease, and that Dr. Kandel’s conclusion that seeing these types of experiences as brain diseases immediately destigmatizes it, is at the very least, questionable.

Are Disorders of Mental Functioning Properly Viewed as Brain Diseases?

Colony of pathogen bacterias - 3d render
Colony of pathogen bacterias

Physical pathologists, who are trained in the principles of science, determine if a pathological condition is present by looking for a set of objectively observable body conditions such as tumors, microbe infections, tissue tears, bone fractures, and blocked arteries. None of these have been identified by pathologists as causing the conditions typically labelled by psychiatrists as mental illnesses. If they were to find the physical pathology that causes any of the behavior patterns referred to as mental illnesses, that pattern would no longer be referred to as a mental illness. Instead, the pattern would be viewed as the symptoms of the  physical pathology, and the disease would be referred to either as the type of pathology (tumor, microbe infection, etc.) or the name of the person who discovered the relationship between the behavior pattern and the physical pathology.

Dr. Kandel, when trying to make the case that mental illnesses are real brain diseases has, at times, cited articles that show some correlation of a brain difference with some of the concerns that lead to a mental illness label. But these correlations are far too weak to demonstrate they are causing these types of concerns. For example, people labeled as having schizophrenia have, on average, some larger brain ventricles. However, there are many people who have the same size ventricles, or even larger ones, who show no signs of schizophrenia. Moreover, numerous people who have smaller than average size ventricles are regularly classified as having schizophrenia. Thus, quite clearly, it is not the size of the ventricles that are causing the schizophrenic behavior pattern. It is for this reason that the size of one’s brain ventricles is not used to make the so called diagnosis of schizophrenia. Instead, doctors rely on a conversation with the designated patient to make these types of so called diagnoses.

Are such conversations properly viewed as objective criteria for determining a disease state and equivalent to observing the type of pathologies that physical pathologists look for in identifying a disease state? Numerous critics of psychiatry say no. They point to what highly credentialed doctors have, over the course of history, claimed are mental illnesses.

Dr Samuel Cartwright
Dr. Samuel Cartwright

For example, in 1851 American physician Samuel A. Cartwright labelled black slaves who tried to flee captivity as having the mental illness of drapetomania. For people who hold the value judgment that the function of healthy blacks is to be slaves, then it certainly makes sense to say that blacks seeking to flee captivity were being dysfunctional.

Freud Practicing the Dysfunctional Habit of Smoking
Freud Practicing the Dysfunctional Habit of Smoking

If you are religious, many highly credentialed medical doctors, including Sigmund Freud, who, like Dr. Kandel, won a Nobel Prize, have claimed this meant you had a mental illness. People who are gay were declared as having a mental disease here in the US. In the former Soviet Union, if you were opposed to communism it warranted a mental illness label by their psychiatrists. In each of these societies, a case was made that the behavior pattern labelled as a mental illness was dysfunctional.

New-quote-from-William-JamesThe argument that such labeling practices are not scientific, but, rather, value judgments, was intelligently made by William James when he defended the religious sentiment. He explained that pathologizing these sentiments as mental diseases was superficial medical talk. He called the reasoning doctors used to declare religious beliefs a type of mental illness, “medical materialism.”

Medical materialism seems indeed a good appellation for the too simple-minded system of thought which we are considering. Medical materialism finishes up Saint Paul by calling his vision on the road to Damascus a discharging lesion of the occipital cortex, he being an epileptic.

Woman of Religious Faith
Woman of Religious Faith

It snuffs out Saint Teresa as an hysteric, Saint Francis of Assisi as an hereditary degenerate. George Fox’s discontent with the shams of his age, and his pining for spiritual veracity, it treats as a symptom of a disordered colon. Carlyle’s organ-tones of misery it accounts for by a gastro-duodenal catarrh. All such mental overtensions, it says, are, when you come to the bottom of the matter, mere affairs of diathesis (auto-intoxications most probably), due to the perverted action of various glands which physiology will yet discover.

James goes on from here to point out that it is true, of course, that psychology has found that there are definite psychophysical connections that “hold good.” Psychology, therefore:

brain-disease-3assumes as a convenient hypothesis that the dependence of mental states on bodily conditions must be thoroughgoing and complete. If we adopt the assumption, then of course what medical materialism insists on must be true in a general way, if not every detail…. But now, I ask you, how can such an existential account of facts of mental history decide in one way or another on their spiritual significance? According to the general postulate of psychology just referred to, there is not a single one of our states of mind, high or low, healthy or morbid, that has not some organic process as its condition. Scientific theories are organically conditioned just as much as religious emotions are; and if we only knew the facts intimately enough, we should doubtless see “the liver” determining the dicta of the sturdy atheist as decisively as it does those of the Methodist under conviction anxious about his soul. When it alters one way the blood that percolates it, we get the Methodist, when in another way, we get the atheist form of mind. So of all our raptures and our drynesses, our longings and pantings, our questions and beliefs. They are equally organically founded, be they religious or of non-religious content.

James points out that in the natural sciences it never occurs to anyone to refute opinions by putting down their authors’ neurological constitutions. Value is determined by “judgments based on our own immediate feelings primarily; and secondarily on what we can ascertain of their experiential relations to our moral needs and to the rest of what we hold as true.”

brain-diseaseAll states of mind are related in extremely complex ways to neural functions. There is a crucial distinction to be made between a brain difference and a brain pathology. The significance of each state of mind must be tested, not by some neurological difference, but by the value of its fruits. When the term “pathological” is applied to an experience, rather than an identified physiological pathology, it wrongly implies a neutral science classification.

In my view, what William James says about the religious sentiment and disease states hold just as true for people who are currently declared as having a mental illness by Dr. Kandel and many other doctors. They declare, in a very subjective manner, patterns of behavior are due to a brain disease without objective proof that there is a physical pathological condition causing the pattern. They don’t make a distinction between a brain difference and a brain disease. And they don’t deal effectively with the fact that there are numerous people who display patterns that have been viewed by the psychopathologizing doctors who have brought forth some of the greatest fruits known to the human race.

Calling Mental Illness a Brain Disease: Does It Stop Stigma?

brain-disease-6

In the above Aldous Huxley quote, apparently it was his opinion that all the normal people in our society are dysfunctional, and thus psychiatry might want to declare all normal people as having a brain disease. I wonder if all normal people might feel less stigmatized upon hearing about this pathologizing of their experiences. Hmmm.

Anyway, if you will, let us turn to Dr. Kandel’s declaration that by getting people to see that mental illnesses are brain diseases it destigmatizes them immediately. He offered no scientific evidence for this. When we actually look at the evidence bearing on his statement, we get a very different impression.

Lincoln, sufferer of depression
Lincoln, sufferer of depression

Very modest evidence exists indicating people who have become convinced that mental illnesses are brain diseases are somewhat less likely to blame labeled persons for their behavior. However, at the same time, overall stigma actually increases. Biological explanations, for many, imply that people with mental illness are fundamentally different or less human.

Research has also shown, that disease explanations for mental illness provoked harsher behavior toward labeled persons. It is worthwhile keeping in mind that in the not-so-distant past, biological and genetic explanations for stigmatized conditions were linked to a range of harsh policies, including marriage restrictions, sterilization, lobotomies, and even extermination.

Painter who has been said to suffer from mental illness
Painter who has been said to suffer from mental illness

The biological explanation may also exacerbate yet another key stereotype of mental illness, the belief that people with mental illness are dangerous. Many researchers believe that the stereotype that people with mental illness are violent ranks among the most prejudicial and discriminating of attitudes. Unfortunately, there is evidence that biological arguments may actually strengthen dangerousness stereotypes, suggesting that people with mental illness have no control over their behavior and therefore are unpredictable and violent.

brain-disease-5In contrast to biological arguments, psychosocial explanations of mental health concerns have been found to effectively improve images of people who are now being labeled as having a mental illness. It also appears to reduce fear.

Instead of arguing that mental illness is like any other medical illness, psychosocial explanations of mental health concerns focus on environmental stressors and trauma as causal factors. These may include childhood abuse, poverty, and job stress. The idea is to reframe mental health concerns as understandable reactions to life events.

Conclusion

Socrates heard voiced in his head and was condemned to death by society leaders.
Socrates heard voices in his head that he referred to as guiding demons and was condemned to death by society leaders.

The mental health concerns that most modern day doctors refer to as mental illnesses, have not been shown to be caused by a physiological pathological condition. There are undoubtedly some brain differences that have been correlated with a few types of concerns, but it is way too simplistic to say that such differences are the cause of any of these concerns. It is very possible that environmental and cultural factors may lead to the observed correlations. Despite the fact that a person might be said by some that he or she is functioning below average in some ways under some societal situation, numerous examples can be easily provided that people labeled mentally ill have often produced valued fruits in the fields of science, arts, and philosophy. Finally, labeling someone experiencing a mental health concern as having a brain disease does not automatically decrease stigma, and could actually increase it.

———————————
Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.