Categories
antipsychotic drugs Ethics in Mental Health Care Ethics in psychiatry psychiatric drugs psychiatric medications

Cool Steve Deals With A Psychiatrist

Dr. Jeffrey Rubin

Welcome to From Insults to Respect. Today, I ask readers to consider a story that raises some questions regarding the practice of psychiatry.

The Story

     Cool Steve and three of his fellow high school buddies, Jeff, George, and Cliff, have come to the Coney Island Child Psychiatric Center because Steve’s eight-year old brother, Pete, has been dealing with some serious emotional problems. When Pete was first brought to the center, Doctor Goldwin had prescribed Thorazine, to treat Pete. Upon doing some research about the drug, the boys learned it has some serious, and even life threatening side effects. The boys have now come to the center to discuss this with Dr. Goodwin, and while waiting to see him, another psychiatrist, Dr. William Kolanski, comes by. Here’s how Jeff tells what transpires.

     “Excuse me, Dr. Kolanski,” I call out just as he’s shutting his office door behind him.

      Dr. Kolanski reopens his door.  “Can I help you boys?”

     “We’d like to ask you some questions about Thorazine,” says Cliff. “We have some questions about the safety of Thorazine.”

      Dr. Kolanski’s forehead crinkles.  “Oh, I see,” he says.  “I’m afraid I too have some questions about its safety.  I’ve seen, personally, a couple of tragedies that have befallen patients who had been placed on Thorazine and related drugs.  One just occurred last night.”

      As he is speaking, we notice Dr. Goldwin opening his office door and as he begins to listen to Dr. Kolanski, his face begins to turn brick red and suddenly he begins to shout at Dr. Kolanski, “Doctor!  Please step into my office!”

      Dr. Kolanski gets up and walks into Dr. Goldwin’s office.

      “Hurry, Jeff,” whispers George.  “You’re the actor.  Go over by the secretary and as you’re walking by her, create a commotion.  Get her into the hallway with you so she can’t see us.  The rest of us will listen at Dr. Goldwin’s door and hear what’s going on.”

      “Wait a minute,” whispers Cliff.  “If they catch us listening, we’ll be the ones they’ll be injecting with Thorazine.”

      I look at Steve who is bending over with his ear close to Cliff’s mouth.  He straightens up, turns his back to the secretary so his voice won’t project toward her.  I glance over and see the secretary is hard at work typing.  She has blond hair, obviously bleached.

     “Cliff, you’re free to leave,” whispers Steve.

     “If you guys are staying, I’m staying,” whispers Cliff.  “But we’re nuts!”

     Then Steve turns to me. “Go ahead, Jeff,” he whispers. “Do what George said. Hurry.”

     What kind of commotion can I make? I think to myself as I head toward the secretary.  As I walk by her, suddenly I scream and grab my leg, falling to the floor.

     “God!  Oh God!  Miss!  Miss!” I shout to the secretary, pretending to be in agony. She leaps up. “Shall I call for a doctor?” she asks, very concerned.

     “No!  No!  It’s just a cramp.  If you could just come over here for a second and help me up.  I get them from time to time.  I just need to walk it off.”  My hand stretches out to her as my face contorts, and I let out a wrenching–“O-h-h-h!”

     She hurries around her desk and helps me up.  I limp, with her support, leading her down the hall. Halfway down I feign another cramp attack. I moan and groan, fall to the floor and clutch my leg.  “I’ll be okay. All I need is some help to walk it off.  It’ll be okay in a second or two. Just help me up again. Oh-h-h-h!”

     I lead her further away from her desk. By the main doorway, I begin to ask her about being a secretary to psychiatrists, while still acting like I’m in distress.  Once she gets to talking, she starts to get lost in what she’s saying for a few minutes. 

     I begin limping slowly when the hallway elevator doors open. An orderly steps out and turns down the hallway toward the chamber where my friends are listening at Dr. Goldwin’s door.

     I have to act fast. I begin yelling, “Orderly!  Orderly!”

     I have no idea what I will say to him, but he stops, turns, and says, “Yes?”

     I explain to him about my leg cramp, and that although the secretary is helping me by holding my left arm, if he could take the other one just until I can get back to the waiting room where my friends can take over to help me.

     I limp, with this assistance, toward the waiting area; and when we’re six feet or so from being able to see into the chamber off to the left, I call out, “Steve!  Cliff!  George!  Could you guys come help me?”

     I pray my warning cries are heard. When the orderly, the secretary, and I enter the chamber, there are the three spies innocently sitting on the waiting area couch.

                                                            *              *              *

As we jump into a taxi, I ask, “What did you find out?”

     “Get this,” says Cliff, obviously annoyed.  “I agree to stay with these nuts, and I didn’t even get to listen at the door.  Steve tells me I gotta watch down the hallway to see if anyone was coming!”

     “I wanted him to stand guard,” says Steve, defending his actions.

     “Well, at least Cliff, you must of felt relaxed knowing no one would surprise you,” I say.

     “Get out of here!” Cliff responds. “There are three doors in the waiting area–Dr. Goldwin’s office, Dr. Kolanski’s, and some other guy’s.  At any second someone might have popped out of any of the doors.”

     “Well, anyway, you didn’t get caught,” I say. “What’d you find out?”

     “First of all,” says George, “Dr. Goldwin is going to try to get Pete committed to the hospital and to force him to take Thorazine. There’s a meeting in a Judge Kaplan’s chambers at 2:00 today.”

      “What else did you hear? I ask. 

       “Dr. Goldwin,” says Steve, “was yelling at Dr. Kolanski, saying,” ‘What the hell do you think you were doing out there?’     “Then Dr. Kolanski said,” ‘We don’t know what we’re doing with this Thorazine, yet. Just last night one of the patients on it became very sick. We need to back up, re-evaluate.’

        “Dr. Goldwin said, ‘Bill, you’re going to have to learn to take a clinically detached view of these cases. Now pull yourself together.  I want you to go out there and tell those boys you thought they were talking about some other medication–Reserpine.  Tell them you thought they were talking about Reserpine.’

      “Dr. Kolanski said, ‘I can’t do that, Robert.’

       “Dr. Goldwin said, ‘Let me make myself clearer, I’m ordering you to do it.’

       “Dr. Kolanski said, ‘You’re ordering me to do something unethical and immoral.’

        “Dr. Goldwin replied, ‘I’m telling you that if you ever want to work as a psychiatrist again, you’ll get out there now and do what I just told you!’

       “Dr. Kolanski said, ‘Robert, Pete’s mother has a right to make an informed and completely voluntary decision concerning treatment for her son.  I intend…’

       “Dr. Goldwin interrupts, hollering,  ‘Informed consent–what crap. You know what kind of patients we deal with.  You think their parents are any better…’

      “Dr. Kolanski then said, ‘Under the law, parents are presumed competent. You presume incompetence. If you think the parent is incompetent to be the boy’s legal guardian, pursue the case in a court of law. At least there she’ll be entitled to due process.’

       “Dr. Goldwin then said, ‘Who the hell do you think you’re talking to?  Who the hell… you want us to get rid of drugs, do you?  What are we supposed to do, talk to the patient? That’s what the social workers and psychologists do. You know what they get paid around here?  Do you know what I paid for my brownstone on 57th Street? You’re fired, Dr. Kolanski.'”

Discussion

This story raises some important questions. For example, do you respect Dr. Kolanski for seeking to be honest with Steve and his friends? Did Dr. Goldwin do the right thing by firing Dr. Kolanski? How do readers feel about Dr. Goldwin raising the issue of having a much higher salary than social workers and psychologists because of his prescription privileges?

I encourage readers to chime in on these questions and comment in any other way that comes to mind.

My Best.
Jeff

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE

Categories
antidepressants antipsychotic drugs conflict resolution mental disorders Mental Illness

Psychiatry, Science or Business Model?

Welcome to From Insults to Respect.

Last week, I presented a post titled, “Mental Illness as Distress, Abnormality, and Dysfunction.” There, I explained that it is actually normal in our society to have periods during which we become concerned that we are too distressed, or too dissatisfied with our level of functioning. The pharmaceutical companies, I noted, promote that these concerns are mental disorders and can be safely addressed by going to a psychiatrist.

Psychiatrists, using the Diagnostic and Statistical Manual of Mental Disorders-5th Edition (DSM-5), label expressed concerns as mental disorders, and then write prescriptions for drugs they call medications. This is financially rewarding for psychiatrists and makes billions for the drug companies. Unfortunately, this model is promoted as a sound science supported enterprise, although science paints a dramatically more complicated picture.

The question of whether psychiatry is even properly viewed as a science was taken up in an article titled, “Is Psychiatry Scientific? A Letter to a 21st Century Psychiatry Resident.Published in 2013 by the National Library of Medicine, its conclusion section states in part, “The DSM-5 is a dead end, and even the NIMH scientists acknowledge that DSM-5 does not describe valid entities supported by valid scientific research.” Nevertheless, on the basis of this approach, the average psychiatrist makes $220,000 per year.

Here’s a narrative illustrating what they do to earn this.

Good afternoon, Mrs. Doe. I hope your trip here went smoothly.

Yes. I’ve come for an appointment, Dr. Smith, because I’ve been very depressed. I’ve been seeing on TV commercials that there are some pills that can help.

Yes, Mrs. Doe, there are. But first, please tell me how long these depressed feelings have been going on.

Well, my husband and I have begun the process of having a divorce, and, well even before that, we were having marital problems, and, well, maybe for a few months now its been pretty bad.

Has it been affecting your sleep?

Oh, yes. I often have trouble falling to sleep for hours.

How about eating?

Sometimes I end up drinking too much, and I have a bad stomach reaction….

After this type of conversation goes on for about an hour, the doctor prescribes a pill, informing the patient of what kinds of side effects to watch out for.

Psychiatrists, like other medical doctors, seek to validate their treatment with studies that are carried out using acceptable scientific methodologies. Let’s take a critical look at the outcomes of these studies.

The Science

Short term studies indicate the use of “antidepressants” can cause irritability, anxiety and panic, emotional flattening, involuntary muscle movementssexual impairment, suicidality, weight gain and aggression. Additionally, serious withdrawal effects are well-documented and can last for months, and can be mistaken for a return of depressive symptoms. 

In these short term studies, some subjects taking these drugs do report some improvement after a few weeks, but so too do those who take a placebo, or begin a physical exercise program, or begin seeing a counselor or psychotherapist, or begin to meditate. The difference between the  improvement experienced between the active drug and placebo groups tends to be slight.

Even this slight improvement has been questioned because of serious flaws in the research design. These flaws have to do with the drug studies being funded by pharmaceutical companies and because most of the subjects in the studies were taking a different “antidepressant” prior to the study.

Why would taking a different “antidepressant” prior to taking the new drug in these studies lead to making the new drug look more effective than a placebo? To qualify to be in the study, those who had been taking a different “antidepressant” had to agree to stop taking it for a couple of weeks prior to taking the new “antidepressant.” It often takes more than two weeks to wean off of these types of drugs. Therefore, many of these subjects in the placebo group were experiencing withdrawal reactions from no longer taking any “antidepressant.” This then creates the illusion that the new drug is more effective than a placebo because those taking the placebo mistake their withdrawal reaction that is continuing after they begin to take the placebo to a worsening of depression. Meanwhile, those in these studies who were taking the actual new drug are less likely to experience withdrawal reactions because new “antidepressants” are similar to the older ones. 

As for the long term effects of these drugs, there are some studies that looked at this and found that those who took “antidepressants” had worse outcomes than those who did not receive the drug despite having the same symptoms.

I focus above on the science regarding depression because it is the most common reason people go to a psychiatrist, but all of the drugs psychiatrists tend to prescribe are unhealthy. The so called “antianxiety” drugs, colloquially called “benzos,” are addictive, and side effects include drowsiness, dizziness, and decreased alertness and concentration. Lack of coordination may result in falls and injuries. Another result is impairment of driving skills and increased likelihood of traffic accidents. Decreased libido and erection problems are also common side effects. Depression and disinhibition may emerge.

The so called “antipsychotic” drugs are even more dangerous. Here’s a list of them, and I provided a link for each one so people can learn more about what they are.

Some estimates suggest the “antipsychotics” shorten a person’s life by around 10 to 20 years. That’s a lot of damage to cause.

My Conclusions

Dr. Jeff Rubin

For several years, I moderated a series of debates on this topic. The panel members included several leading psychiatrists who supported what they did in their practice. I came away fairly convinced that they genuinely believed they were providing an enormously helpful set of treatments. They also struck me as intelligent, caring individuals, and I respected them for their willingness to debate the issues.

Their efforts at rationalizing what they do consists of describing their experience with their patients in glowing terms, minimizing the negative side effects while exaggerating the benefits of the drugs they prescribe, and admitting that much of the scientific support for their treatments are indeed flawed but set this quickly aside with comments like, “Hey, all research studies have flaws.” Even in the face of other debate panel members that included one psychiatrist, a noted scientist, and patients who disagreed with them, they steadfastly remained convinced that their approach was consistent with the best science available.

These debates also included patients who fervently believed the psychiatric/mental disorder way of looking at their concerns has been enormously helpful. Their two chief arguments were,

1. Mental illnesses are real illnesses, and therefore, this eliminates blame for what they were going through,

2. The psychiatric drugs have “saved their lives,” or significantly improved their lives.

To this, I want to make it clear that neither I, nor most of the people I know, blame patients/clients for experiencing psychological concerns regardless of their views on this issue. At the same time, I have met people who do blame people for any and all behaviors they don’t like about them regardless of their views on mental illness. Since the notion of mental illness as real illness has been the dominant position by psychiatrists, stigma has not been eliminated. Moreover, I know smart, intelligent people who choose to take psychiatric drugs that I genially like and respect. With those words of clarification, I nevertheless have, after hearing both sides of these issues, concluded psychiatry causes far more harm than good, while being a heck of a financially rewarding business model.

It’s hard to come to this conclusion because making a good living is a fine thing to be doing. I don’t want to be seeming to be putting down the value of this, and I fear that people might think I have unkind feelings toward psychiatrists in general. I recognize and accept good people see these issues so very differently than do I.

Well, enough for now on this so very challenging topic. Let’s depart with a shift to something more pleasant.

Spring has arrived, along with its beautiful, colorful flowers fluttering in fragrant breezes. And so, may we all find some time to get outside, breath deeply, and find within us a wonderful appreciation of the many fine aspects of being alive.

My Best,
Jeff

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.

Categories
antipsychotic drugs antipsychotics and mortality conflict resolution Schizophrenia

Do “Antipsychotics” Reduce Longevity? A Robert Whitaker Analysis

Welcome to From Insults To Respect.

Back in 2019, I criticized the use of “antipsychotics” and on Facebook someone criticized what I had written saying, “all of the research clearly indicates that the “antipsychotics,” when used by people diagnosed as having schizophrenia, decrease the risk of dying.” I then, very respectfully, asked that he supply me with the references that he is relying on to make his assertion, and within a very brief period, he did just that.

In looking at his list, I noticed immediately that he left out every one of the studies that provided strong evidence published in peer reviewed articles that suggest this class of drugs actually reduces longevity. For example, a 2007 study was published in the Archives of General Psychiatry titled “A Systematic Review of Mortality in Schizophrenia: The Differential Mortality Gap Worsening Over Time.” The authors wrote:

Mental health services have advanced in many parts of the world during the past few decades. Apart from a different mix of community-based care, the introduction of the second-generation antipsychotic medications [also referred to as atypical antipsychotics] in the early 1990s was initially found to be associated with better quality of life and reduced risk of relapse.7779 More recent trials have questioned the clinical superiority of second-generation antipsychotic medication,80,81 and concern is now widespread about the adverse effects associated with these medications.82 In particular, compared with typical antipsychotics, several of the second-generation antipsychotics are more likely to cause weight gain and metabolic syndrome.83 Because the metabolic syndrome is associated with a 2- to 3-fold increase in cardiovascular mortality and a 2-fold increase in all-cause mortality,84 these adverse effects would be expected to contribute to even higher SMRs [Standard Mortality Ratio] in the next few decades.85,86

After summarizing the many studies revealing these types of troubling findings, I then took a look at the studies that were cited by the person who criticized my position, and wrote up my findings (see HERE).

I don’t know where this person obtained his list, but it appeared to me, as I began to study it, that it was probably made by a pharmaceutical industry salesperson who goes to doctors’ offices to convince them to prescribe their drugs. I say this because there are articles on the list that had titles that sounded like they were relevant, but when reading them, they were not. For example, the first study on my critic’s list was published in The Lancet in 2018, and titled “Second-generation Antipsychotic Drugs and Short-term Mortality: A Systematic Review and Meta-analysis of Placebo-controlled Randomized Controlled Trials.” It looked at 596 studies, all of which looked at patients that were randomly assigned to either an “antipsychotic” or a placebo for 13 weeks or less. For the patients in this analysis that had been labeled as having schizophrenia, there was no statistically significant difference in mortality between the two comparison groups.

Upon reading this article, I was left puzzled. Why was this article included in my critic’s list. As I have said, his contention was that every research paper published demonstrated “antipsychotics” decrease mortality for schizophrenia labeled individuals, which was not supported in this study. 

In another study on the list, “Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of Patients in Community Care After First Hospitalisation Due to Schizophrenia and Schizoaffective Disorder: Observational Follow-up Study,” published in 2006 in the British Medical Journal, the most important finding is that patients that were on “antipsychotics” for less than 6 months had a lower rate of dying than those who were on the drug for longer periods. The authors note this in the results section of their article with a single sentence, stating,”Patients who used antipsychotics for less than 6 months had especially low mortality rates.”

However, if you read just the abstract of the article, as many practitioners do because time reading research studies is not billable, you would find no mention of this statistically significant finding, a finding that could have life saving implications.

After completing my review of the various studies on my critic’s list, I concluded that the studies claiming support for the notion that “antipsychotics” increase longevity are seriously flawed and the weight of the evidence indicates they do just the opposite.

Since my analysis, Robert Whitaker, to my mind the premier science writer on psychiatric drugs, published an article in the peer reviewed research journal Psychological Medicine. The article is titled “Do Antipsychotics Protect Against Early Death? A Critical View” (see HERE). The journal is published by Cambridge University Press, and to read it you have to have a subscription to the journal. Fortunately, Whitaker has made his findings available for free HERE.

Whitaker’s article covers much of the same territory as my own, but he adds some insightful additional analyses so worth considering that I want my readers to become aware of its existence. After all, the information addresses life and death issues.

As I have said, Whitaker’s analysis is freely available. However, because he so thoroughly covers the relevant research it is rather long. Therefore, to make his analysis more accessible to a wider audience, below I provide a few of his summary statements.

Whitaker’s Summary Statements

As can be seen in the research summarized to this point, there are compelling reasons to conclude that these drugs contribute to early death. To wit:

  • Both first-generation and second-generation antipsychotics cause adverse effects that are known to increase the risk of dying from cardiac, respiratory, and endocrine diseases.
  • Psychiatric users of antipsychotics die at high rates from these somatic illnesses.
  • Non-psychiatric patients who use these drugs also die at elevated rates from these illnesses.
  • In both psychiatric and non-psychiatric patients, the use of antipsychotics doubles the risk of death in comparison to matched cohorts of patients who do not take the medications.
  • Studies of smaller cohorts of schizophrenia patients have found that antipsychotic use is associated with elevated rates of death, with this risk rising with higher doses and polypharmacy.
  • Suicide rates for patients diagnosed with schizophrenia are dramatically higher in the antipsychotic era than in the pre-antipsychotic era, and this risk soars during the first year after initial treatment with an antipsychotic in the hospital.

…A number of longer-term studies have found higher recovery rates for those off medication. Add in research findings that antipsychotics shrink brain volumes, with this shrinkage associated with cognitive decline and a worsening of negative symptoms, and psychiatry is confronted with an “evidence-based” crisis.

The “antipsychotics lengthen lives” research gave the field a new claim to hang onto and to promote. A treatment for a disease that increases survival…can lay claim to being effective. During a time of doubt, that is a conclusion that provides a sigh of relief—and comfort—for the field.

But as can be seen in this review, that belief arises from research that is flawed in so many ways. There is evidence, time and again, of a process that was designed to justify the long-term use of antipsychotics, rather than honestly assess their impact on mortality.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.

Categories
Alternative treatments for psychosis antipsychotic drugs conflict resolution

If Not Antipsychotics, Then What?

Welcome to From Insults to Respect. Today we once again take up the controversial topic of the usefulness of the group of drugs referred to by psychiatrists and the pharmaceutical industry as “antipsychotics.” In most of the articles that I have read that have been written by psychiatrists, “antipsychotic” drugs are the first line of treatment for schizophrenia. And yet, a growing number of mental health advocates have been fiercely critical of this. As someone who has given considerable thought to helping people resolve challenging conflicts, I set myself on trying to find out what is going on here. After a review of the scientific research and participating in several debates, I then wrote three blog posts that reported to my readers what I have found.

In the first post, I conclude that the weight of the evidence indicates these drugs are causing far more harm than good. In the second post, I explain how people come to have the illusion that these drugs are helpful. Upon publishing the first two posts, several defenders of the use of these drugs claimed these drugs are worth using because they reduce the risk of early mortality. I, therefore, published a third post that reviews the mortality research studies. As it turns out, some rather weak evidence does exist that appears to support a positive correlation between “antipsychotic” use by those labelled as having schizophrenia and reduced early mortality. However, those studies have significant flaws and more convincing evidence exists suggesting these drugs actually increase the risk of early mortality.

A recent article published in the prestigious medical journal The Lancet, succinctly summarizes much of this research:

[The evidence] “shows that many patients choose to refuse or discontinue their pharmacological treatment…. Patients with psychosis are often ambivalent about taking drugs, and evidence suggests that the effectiveness of such drugs has been overestimated, whereas the severity of their adverse effects have been underestimated. A systematic review concluded that the improvements claimed for antipsychotics are of questionable clinical relevance, and a multiple-treatments meta-analysis showed that although differences in efficacy between antipsychotics and placebo were noted, they were smaller than those for most of the analysed adverse effects. Research suggests that adverse effects include structural abnormalities in brain volume, increased risk of sudden cardiac death, and substantial weight gain induced by antipsychotics, which is associated with cardiovascular and metabolic risks.”

In addition to the adverse effects and lack of clinically meaningful positive effects, there is an enormous cost to using these drugs, costs that are siphoning off resources that could be better used for more healthy alternatives. The cost for the drug approach is not just confined to the cost of the “antipsychotic” drugs which has been estimated to be in the range of several billions of dollars. Doctors often prescribe a whole cocktail of drugs for these patients, dramatically adding to the cost of the drug approach, while evidence indicates the combination of “antipsychotics” with these other drugs often leads to additional adverse effects. The cost of the doctors’ time for prescribing and monitoring the treatment must be added, as well, as the cost of the revolving door of placement in a hospital, releasing from the hospital, and readmitting to the hospital, which has been the frequent pattern with this drugging approach. Finally, we must add the cost of treating patients for all of the adverse effects of these drugs.

Given all of these problems, what alternatives to “antipsychotic” drug management are out there?

The Alternatives

There are several very promising alternatives, but in most regions they are not yet available. Articles like mine are designed to expand the general population’s knowledge of just how ineffective, harmful, and financially wasteful the drug treatments are, and that there are safer alternatives. This increased awareness campaign has been a major reason for the slow rising tide of advocates demanding that these more healthy alternatives become readily accessible in every community.

With this background, let’s take a look at these more healthy, humane alternatives.

Cognitive Therapy

study funded by England’s National Institute for Health Research was published in 2014, that carried out a single-blind randomized controlled trial. Participants aged 16–65 years who were labelled as having schizophrenia spectrum disorders, and who had chosen not to take antipsychotic drugs, were randomly assigned to either receive cognitive therapy plus treatment as usual, or just treatment as usual. Outcome assessors were masked to group allocation.

The authors summarized their results as follows:

“Cognitive therapy significantly reduced psychiatric symptoms and seems to be a safe and acceptable alternative for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs. Evidence-based treatments should be available to these individuals. A larger, definitive trial is needed.

The central features of this treatment for this group of patients involve normalization and evaluation of the appraisals that people make, helping them to test such appraisals with use of behavioral experiments, and helping them to identify and modify unhelpful cognitive and behavioral responses. Additionally, it aimed to provide warm, empathic, and non-judgmental face-to-face contact, supportive listening, signposting to appropriate local services for unmet needs, and crisis management when needed.

Treatment as usual was variable across both sites. In practice, participants within these services received regular care-coordination and psychosocial interventions, including the offer of family interventions.
On average, neither group deteriorated over time, in a population that has been assumed to deteriorate without total adherence to drugs; in fact, some participants receiving treatment as usual who were not taking drugs achieved good clinical outcomes, and more did with the addition of cognitive therapy. The study also showed that cognitive therapy is an acceptable intervention for a population who are usually considered to be very challenging to engage by mental health services, with low rates of drop out and withdrawal. The effect size on psychiatric symptoms in the study is similar to the median effect size reported for overall symptoms in a large meta-analysis of 15 antipsychotic drugs versus placebo.

Humanistic Approaches

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A recent issue of the Journal Of Humanistic Psychology (JHP) is devoted to the humanistic perspective on understanding and responding to extreme states. There you will find several non-antipsychotic approaches for addressing psychological concerns that are labelled as schizophrenia by psychiatrists.

In one of the articles, Yana Jacobs, who once worked as a staff member at Soteria House, tells us about its approach. Funded by the National Institute of Mental Health, Soteria House provided a place to live for people who fit the criteria for schizophrenia and having their first episode. These patients were given the choice of staying at the hospital where they had first been labelled, or coming to Soteria, where “antipsychotics” usually would not be used. As Yana describes the program,

“All six residents were given their own private room and had the freedom to do what they felt like. This might include staying in their bedroom, sleeping all day, or hanging out in a living room and listening to music or chatting with whomever was around. Relationships developed naturally, and we all got to know one another to various degrees, no different than how we develop friendships. This was not a therapist-patient relationship but rather a sort of social relationship. As a staff member I had some responsibilities—going to the market and preparing dinner. Everyone was on their own for breakfast and lunch and could help themselves to whatever they might like. Grocery shopping was often an outing to the market. Usually, one or two residents would accompany me to the store. When we returned, I would ask for help prepping the meal. It was quite informal. The house was often a bit of a mess, but then, we’d all get together and decide it was time for a quick house cleaning and again, whoever wanted to join would do so.”

For those who have come to believe that without the use of “antipsychotics” all hell would break out and the world would pretty much come to an end, consider Yana’s experience:

“I never felt like I was ‘working,’ and honestly, I loved being at Soteria so much that it wasn’t till the end of my employment that I even took note of how much I was being paid. There’s something about being with people when they are going through a difficult time that is such a privilege and truly an honor to be part of this intimate journey.”

Yana explains that there were times when someone was going through deep pain, tears, screaming, throwing things, and sleeplessness, “but always something would emerge and calm would eventually arrive, you really had to have faith in the process.”

Since the original Soteria House opened and funding ran out, several other programs based on a similar model took its place. Berne, Switzerland has had a Soteria House since 1984, and Soteria houses in Vermont and Israel recently opened.

Soteria House programs are designed to help people through an original episode of an extreme experience typically labeled as schizophrenia. The stay at one of these houses lasts for just a few months.

Another approach well described in the JHP special issue is written by Charles Knapp. The Windhorse therapeutic perspective has a Tibetan Buddhist orientation that offers meditation, and spiritual teachings, along with a supportive, empathetic staff. Unlike the Soteria House approach, which aims to support people through a recovery process over a few months, the Windhorse approach recognizes that individual recovery periods are highly variable, and it is not uncommon for people to stay in their programs for eighteen months and even longer.

There are several other approaches described in the JHP special issue, all worth while to think about. All have had their share of success in helping to provide support for people experiencing extreme states.

That said, I would be negligent if I didn’t say that no approach currently available manages to avoid having some disappointing results. This is true for the standard medical model which urges all people labelled as having schizophrenia to immediately take “antipsychotics,” and it is also true for all of the alternative approaches discussed above. However, those alternatives lead to far fewer people eventually choosing to take “antipsychotics,” thus decreasing the chances of people experiencing the various adverse effects associated with consuming “antipsychotics.”

Beyond the decreased risk of “antipsychotic” adverse effects, available research can not say for sure that these alternatives lead to additional improved life outcomes. Nevertheless, results have been very encouraging, and it is high time that these alternatives become far more accessible while high quality ongoing research better assesses what works well, and what needs to be modified.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.

Categories
antipsychotic drugs conflict resolution psychiatry Schizophrenia

Antipsychotics: The Illusion That They are Helpful

Welcome to From Insults To Respect.

Last year I published a post titled “Are Antipsychotics Beneficial?” (see HERE).

Robert Whitaker

Although I had personally reviewed the research, I relied on my method of presenting this information to readers by summarizing a free PDF written by the highly regarded science writer, Robert Whitaker, titled, “The Case Against Antipsychotics: A Review of Their Long-term Effects.” By clicking on the blue title, you can read all of his arguments.

Whitaker’s most recent book, Anatomy of an Epidemic, provides an in-depth exploration of medical studies, and concludes that there are serious problems with the conventional wisdom of treating those labeled as mentally ill with drugs.

Toward the end of my post on antipsychotics, I provided the following quote from Whitaker’s free PDF:

“The drugs are supposed to provide the benefit of reducing psychotic symptoms. antipsychotic handBut the research reveals that, over the long term, this benefit turns into a negative, and so, over the long-term, there are only negatives to be chalked up: the increased chronicity of psychotic symptoms, the impaired functional outcomes, the worse cognitive functioning, and, of course, a broad range of “side effects,” such as tardive dyskinesia, metabolic problems, sexual dysfunction, and so forth. Such is the bottom-line arithmetic that makes the case against antipsychotics.”

In my post, I ended up supporting Whitaker’s conclusions.
Consequently, some of my readers showered me with praise for having the courage to stand up to the powerful pharmaceutical-psychiatric institutions, while others showered me with the most disrespectful insults known to the human race. And then there were those who disagreed with me but did so in a respectful manner. I believe it is my responsibility to now provide them a respectful response.

Those disagreers who remained respectful put forth basically two types of arguments. The most common of these were from people who personally know a family member or friend who has been “diagnosed” as having schizophrenia and from their observations the “antipsychotic” drug treatment appears to be helpful.  Others had seen some research that has convinced them that the drugs reduced the risk of death.

My post today will focus on the first of these arguments. I review the evidence regarding whether or not these drugs reduce the risk of death HERE.

The Apparent Helpfulness of Antipsychotic Treatment

Any pill prescribed by a doctor will lead many to experience a placebo effect, which can be, for a period of time, helpful. I hasten to point out that a person can get a placebo effect with non-drug treatment approaches as well, and this would avoid the various harms associated with this type of drug.

In addition to a placebo effect, the perception of helpfulness of a drug can come about when a patient in an agitated state first comes to the attention of a psychiatrist. These drugs are not only known as “antipsychotics,” but also “major tranquilizers,” because they sometimes do appear to calm someone in distress.

Unfortunately, once someone begins to take these drugs to help with agitation, when they try to come off of the drug, they are left with drug withdrawal experiences that have been described as awful. I hasten to point out that there are other ways to help someone to calm down that need not rely on these types of drugs. I have worked on many occasions with people who are agitated, and without the aid of a drug prescription I listened in a caring way, and in time the person eventually calmed down. If, however, you give someone a drug that calms the person down, it is sometimes much easier, and less time consuming. For people who witness someone they care about in high distress drift into a calmer state upon taking an “antipsychotic,” this can seem enormously helpful.

Moreover, for a period of several months, the person who had been experiencing some mental health concern might, after taking these types of drugs and being a bit calmer, may begin to function better in several ways, such as sleeping more soundly, or having friendlier relationships.

Some of them would have recovered in a fairly short period without the drug, but because they recovered while taking the drug, they, and their loved ones, attribute the improvement to the effectiveness of the drug. If the person tries to see whether the improvement was due to the drug or the natural recovery process, he or she may try to stop ingesting the drug.
However, the withdrawal from the drug, as I mentioned above, often causes a nasty physiological reaction which, in some ways, is similar to someone who is a coffee drinker who suddenly decides to stop, cold turkey. However, the “antipsychotic” physiological withdrawal reaction can be experienced as much worse. When people who care about this person see the downward spiral that occurs from the physiological withdrawal reactions, they may come to attribute it to the person’s “mental illness” returning, and thus, the illusion of long term effectiveness is now deeply entrenched.

Another way in which the illusion of the long term effectiveness of the drugs can occur has to do with the fact that even when the “diagnosed” person is not functioning well on a drug treatment regimen, human beings can always imagine that the patient would be doing even worse without taking the drug. And of course, when the patient does try to go off the drug, the raging physiological withdrawal process occurs. So, in this way, the combination of the belief that the patient could be doing worse, and upon becoming worse when trying to do without the drug, it convinces people that the drug treatment is helpful.

Finally, oftentimes family members are the ones who had advocated that the distressed person go to a psychiatrist and comply with the drug treatment. Once they take that position, and tell others what they had done, information that comes their way in the form of the distressed person having bad side-effects, or hearing from people who take the position that the drugs may be more harmful than helpful, a psychological phenomenon known as cognitive dissonance occurs. The principle of cognitive dissonance states that human beings strive for internal psychological consistency. When they experience internal inconsistency they become psychologically uncomfortable and a major way that they try to reduce the discomfort is by avoiding circumstances and contradictory information likely to increase the magnitude of the cognitive dissonance.

So, in summary, the five ways that people may get the false impression that over the long term the drugs are effective are:

  1. The placebo effect,
  2. The initial calming effect of the drug,
  3. Attributing observed improvement as being due to the drug rather than to the natural course of the experience,
  4. Whenever the drug taker is not doing well, it is easy to imagine he or she would be doing even worse if he or she was not taking the drug,
  5. Cognitive dissonance.

(By the way, upon reading this, if some of you who have been taking these types of drugs decide that you want to try to wean yourself off, a good resource to help can be accessed HERE.)

Maybe I’m the One Suffering From Cognitive Dissonance

I have publicly supported the argument that these drugs cause more harm than good. Therefore it can be argued, it is I who suffer from cognitive dissonance whenever evidence comes my way that might support the idea that these drugs are helpful in the long run.

This point is worth considering. What I have done to avoid falling into this trap is to thoroughly review the research regardless of whether or not it supports my position. Here’s a partial description of what I found.

By the late 1990s, investigators had reported that antipsychotics caused basal ganglion structures and the thalamus to swell, and the frontal lobes to shrink, with these changes in brain volumes “dose related.” Then, in 1998, Raquel Gur, from the University of Pennsylvania, reported that the swelling of the basal ganglia and thalamus was “associated with greater severity of symptoms.”

Soon Nancy Andreasen, who was then editor-in-chief of the American Journal of Psychiatry, reported on her findings from a study of 500 schizophrenia patients. In 2003, she reported that their frontal lobes shrank over time, and that this shrinkage was associated with a worsening of symptoms and functional impairment, and after five years, with a worsening of cognitive abilities.

While Andreasen initially attributed this shrinkage of the frontal lobes to what she referred to as the schizophrenia disease process, in 2011 she announced that long-term use of the old standard antipsychotics, the new antipsychotics, and clozapine were all “associated with smaller brain tissue volumes.” She found that this brain shrinkage was dose related; the more drug a person was given, the greater the association “with smaller grey matter volumes.” A loss in white matter volume was also “most evident among patients who received more antipsychotic treatment.” Illness severity and substance abuse had “minimal or no effects” on brain volumes, she concluded.

Numerous studies have now reported that antipsychotics induce changes in brain volumes, which, German investigators concluded in 2014, “exert adverse effects on neurocognition, symptoms and psychosocial functioning.”

The MRI studies provide objective evidence that antipsychotics cause changes in brain volumes that are associated with a worsening of symptoms, and a worsening of functional impairment.

So, with all due respect to my critics, I respectfully submit the above argument that the belief that antipsychotics are helpful in the long run is an illusion.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional and social intelligence. To begin at the very first post you can click HERE.

 

Categories
antipsychotic drugs conflict resolution

Are Antipsychotics Beneficial?

illness 4Recently I provided a post titled, “Are Mental Illnesses Really Illnesses? And Why do People Care?” There are a lot of people out there who were very supportive of the post, but at the same time, some were angry that I would even raise the question. One of the most angry person mentioned that the proof that mental illnesses are real illnesses was that the antipsychotic drugs are enormously helpful to people classified by psychiatrists as having schizophrenia.

It just so happens that one of the leading authors challenging that position, Robert Whitaker, has provided for the public a free PDF titled, “The Case Against Antipsychotics: A Review of Their Long-term Effects.” By clicking on the blue title, you can read all of his arguments.

Who Is Robert Whitaker?

According to Wikipedia:

whitakerWhitaker was a medical writer at the Albany Times Union newspaper in Albany, New York from 1989 to 1994. In 1992, he was a Knight Science Journalism fellow at MIT.[2] Following that, he became director of publications at Harvard Medical School.[3] In 1994, he co-founded a publishing company, CenterWatch, that covered the pharmaceutical clinical trials industry. CenterWatch was acquired by Medical Economics, a division of The Thomson Corporation, in 1998.[4]

Whitaker's book coverIn 2002, USA Today published an article of Whitaker, Mind drugs may hinder recovery in its Editorial/Opinion section.[5] In 2004, Whitaker published a paper in the non-peer-reviewed journal Medical Hypotheses, titled, The case against antipsychotic drugs: a 50-year record of doing more harm than good.[6] In 2005, he published his paper Anatomy of an Epidemic: Psychiatric Drugs and the Astonishing Rise of Mental Illness in America in Ethical Human Psychology and Psychiatry.[7] In his book Anatomy of an Epidemic, published in 2010, Whitaker continued his work.[8][9][10]

He has written on and off for the Boston Globe and in 2001, he wrote his first book Mad in America about psychiatric research and medications, the domains of some of his earlier journalism.[11][12] He appeared in the film Take These Broken Wings: Recovery from Schizophrenia Without Medication released in 2008, a film detailing the pitfalls of administering medication for the illness. [1]

Articles that Whitaker co-wrote won the 1998 George Polk Award for Medical Writing[13] and the 1998 National Association of Science Writers’ Science in Society Journalism Award for best magazine article.[14]

A 1998 Boston Globe article series he co-wrote on psychiatric research was a finalist for the 1999 Pulitzer Prize for Public Service.[15]

In April 2011, IRE announced that Anatomy of an Epidemic had won its award as the best investigative journalism book of 2010 stating, “this book provides an in-depth exploration of medical studies and science and intersperses compelling anecdotal examples. In the end, Whitaker punches holes in the conventional wisdom of treatment of mental illness with drugs.”[16]

Judgement word cloud concept
Judgement word cloud concept

What I particularly like about Whitaker’s PDF article is that he defends his position first with the best science-based research articles. Then he acknowledges that other authorities have disagreed with his position. He summarizes their position, and then, point by point, explains why he disagrees with them.

For those who are particularly interested in this topic, I highly recommend that you take some time to study what he has to say.

The PDF is a little long for most of my readers, over 40 pages, so below, I’ll conclude for today with Whitaker’s summary statement.

Summary of the case against antipsychotics

antipsychotic side effectsAs Stip noted in his 2002 paper, there is no compelling evidence in the literature that antipsychotics improve long-term outcomes. The relapse studies do not provide such evidence, and there is no other body of research that does. However, as can be seen in this paper, there is a history of science, stretching across six decades, that consistently tells of a medical treatment that, in the aggregate, does more harm than good.

Here is a chronological presentation of that history of science:

  •  antipsychotic maleThe first long-term study reveals a higher rehospitalization rate for patients treated initially with antipsychotics.
  •  Psychiatrists and other hospital staff describe a new “revolving door syndrome” seen in drug-treated patients.
  •  Bockoven’s retrospective study finds a decline in functional outcomes in the antipsychotic era. 
  • Three experimental studies funded by the NIMH in the 1970s tell of better outcomes with treatment that minimizes antipsychotic use. 
  • One of the lead investigators in those studies, William Carpenter, raises the possibility that antipsychotics induce a change that makes patients more biologically vulnerable to psychosis.
  • antipsychotic femaleGuy Chouinard and Barry Jones, drawing on an emerging understanding of how antipsychotics change the brain, provide a biological explanation of why that would be so. They then test their hypothesis and find that a significant percentage of medicated patients suffer from drug-induced tardive psychosis. 
  • In cross-cultural studies conducted by the World Health Organization, schizophrenia outcomes are found to be much better in developing countries where only a small percentage of patients are regularly maintained on antipsychotics. 
  • antipsychotic brainMRI studies reveal that antipsychotics induce changes in brain volumes that are associated with a worsening of positive and negative symptoms, and adverse cognitive effects. 
  • Animal-model studies lead Philip Seeman to conclude that drug- induced dopamine supersensitivity explains why antipsychotics “fail over time.” 
  • Longitudinal studies in the United States, the Netherlands, and Australia all find that less use of antipsychotics, or no use of the drugs, is associated with better outcomes.That is a robust body of evidence.

Antipsychotics moneyIn order to argue that antipsychotics do not worsen long-term outcomes in the aggregate, all of this evidence would have to be explained away. This entire history of science would need to be discounted. In addition, this review has focused on the benefit side of the risk-benefit equation for antipsychotics. The drugs are supposed to provide the benefit of reducing psychotic symptoms. antipsychotic handBut the research reveals that, over the long term, this benefit turns into a negative, and so, over the long-term, there are only negatives to be chalked up: the increased chronicity of psychotic symptoms, the impaired functional outcomes, the worse cognitive functioning, and, of course, a broad range of “side effects,” such as tardive dyskinesia, metabolic problems, sexual dysfunction, and so forth. Such is the bottom-line arithmetic that makes the case against antipsychotics.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional and social intelligence. To begin at the very first post you can click HERE.