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ADHD ADHD medication ADHD Research Attention Priority Difference

What’s Better, ADHD Or Attention Priority Difference?

Welcome to From Insults to Respect.

Recently, I came upon an article in The New York Times by Ellen Barry titled, “Autism, A.D.H.D., Anxiety: Can a Diagnosis Make You Better?” She begins by telling us about a woman in her early 50s who, upon getting a diagnosis of attention deficit hyperactivity disorder, “described it as a profound relief, releasing her from years of self-blame — about missed deadlines and lost receipts, but also things that were deeper and more complicated, like her sensitivity to injustice.” Other people Ms. Barry met who were given a “diagnosis” of autism spectrum disorder also experienced it as relief. Simply putting a name to it seemed to help.

Negative Effects Emerging

However, Ms. Barry notes that evidence is emerging that over the long term, diagnosing these conditions doesn’t help. “Yes,” she says, “there is a positive effect of lowered self-blame. But there is a negative effect as well–a greater pessimism about recovery.”

Defending her position, Ms. Barry describes a study that looked into this negative effect. The study identified no significant differences in the demographic characteristics or socio-emotional wellbeing of 9-year-olds with hyperactivity/inattention who had and who had not received a diagnosis of ADHD. However, by age 13, those who had a diagnosis at age 9 showed more emotional and peer relationship problems, worse prosocial behaviour, and poorer self-concept.

Other research found that those who were treated with A.D.H.D. medication, in the long run, did no better academically while suffering a variety of negative effects from the prescribed drugs such as becoming addicted to the drug, along with head and stomach aches,

Last year, a study found that even a medium strength daily dose of Adderall, the most commonly prescribed drug to treat A.D.H.D., more than tripled a patient’s likelihood of developing psychosis or mania. A high dose increased the risk by a factor of five. And yet, another study found that the height suppression found in earlier studies, which were thought to be temporary, found that nine years after treatment, the height gap remained. The subjects’ A.D.H.D. symptoms, meanwhile, were no better than those who had stopped taking the medication or who had never started.

Benefits To Realizing The Characteristics That Lead To An A.D.H.D. Diagnosis Are Often Not Permanent

Recent researchers have been discovering that A.D.H.D. behavior characteristics can be highly responsive to the environment. When the surroundings of a person with an A.D.H.D. diagnosis better matches the person’s interests and talents or home life improves, the behavior pattern that led to the “diagnosis” often improves as well.

We need people with different interests and talents to fill the various roles society values. Someone who enjoys painting houses might find sitting all day in front of a computer screen very boring, while others enjoy a job that has them engaging for hours on a computer. Fortunately, we have a need for both types, and conceptualizing one or the other as having a pathological condition does not appear to be helpful in the long run. Much better is to provide narratives that demonstrate people who find they are inattentive in certain settings, such as the typical school classroom, may very well do much better in some other environments better suited to them. More and more, research is demonstrating this is true.

In 2016, Arielle Lasky and other members of her research team published a paper that describes their discussions with subjects who had been given a diagnosis of A.D.H.D. as children, but were now in their mid-20s. Subject after subject spontaneously brought up the importance of finding their “niche,” or the right “fit,” in school or in the workplace. As adults, they had more freedom than they did as children to control the parameters of their lives — whether to go to college, what to study, what kind of career to pursue. Many of them had sensibly chosen contexts that were a better match for their personalities than what they experienced in school, and as a result, they reported that their A.D.H.D. symptoms had disappeared. In fact, some of them were questioning whether they had ever had a disorder at all — or if they had just been in the wrong environment as children.

The work environments where the subjects were thriving varied. For some, the appeal of their new jobs was that they were busy and cognitively demanding, requiring constant multitasking. For others, the right context was physical, hands-on labor. For all of them, what made a difference was having work that to them felt “intrinsically interesting.”

One subject, who was studying film in college, said that his ability to thrive in his chosen field made him question the years he spent being treated for A.D.H.D. “Originally, when I was first diagnosed with it, it was explained to me as attention deficit, just a lack of attention,” he said. “An ability not to have an attention span for very long. But I can have an attention span for extremely long for the things that I care about.”

A hairstylist told the researchers that her inability to concentrate in school vanished when she began studying hair. “If you sit up there and give me a lecture on a haircut, I will remember everything you said, word for word,” she said. “Stuff that I’m into, I am so immersed in it. But in school, it was awful.”

A young man who was training to be an auto technician said that in his new career, his A.D.H.D. was no longer an issue. “It’s just that I had to figure out what I wanted to do,” he explained. “I want to work with cars. I don’t get bored doing that. If people with A.D.H.D. are directed into areas where their strengths and interests lie, I’m pretty sure that they can naturally just go about dealing with it, instead of having to give people medications.”

Instead of characterizing A.D.H.D. as a  medical disorder, which tends to lead people to believe they are defective, perhaps suggesting to them that they may have an “Attention Priority Difference” might be better. For some children, a different school, or a different kind of school, might produce the same profound shift that we are finding in recent research studies.

In a 2021 review paper, researchers found 14 studies in which receiving an A.D.H.D. diagnosis seemed to create a sense of “empowerment” by “supporting a sense of legitimacy accompanied by understanding and sympathy as well as decreased guilt, blame and anger.” In 22 other studies this team found, “a biomedical view of difficulties was shown to be associated with disempowerment. By providing an excuse for problems, a decrease in responsibility by all involved can occur, often followed by inaction and stagnation.” An additional 14 studies found that the diagnosis increased feelings of stigmatization. “The diagnosis can create an identity that enhances prejudice and judgment, which are associated with even greater feelings of isolation, exclusion and shame.”

Conclusion

Admittedly, the  A.D.H.D.medical model provides parents and students a simple explanation for their children’s problems that can bring about relief and reduce blame, at least in the short term. However, the Attention Priority Difference model can do this as well and more accurately reflects the latest scientific understanding that a student’s environmental context can dramatically alter the concerning behavior. Rather than our society spending millions of dollars on drugs that people have become convinced is a quick fix to these problems, the Attention Priority Difference idea can offer for many a valuable alternative. It can motivate schools to provide more varied classroom activities that are designed to better match the various interests and talents of their students who are bored with the traditional approach that has students sitting at their desks doing seat work for unbearably long hours.  And it can give these children a vision of their future in which things might actually improve — not because their brains are chemically refashioned in a way that makes them better able to fit into the world, but because they find a way to make the world fit better with whom they are.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE

Categories
ADHD ADHD medication

ADHD Medications and Risk of Heart Disease

Welcome to From Insults to Respect.

As you no doubt know, a wide variety of people are being classified as having ADHD and prescribed psychiatric drugs. The pharmaceutical industry, with its enormous wealth, promotes the use of these drugs. Supporters of this drug approach often cast a disrespectful eye toward their critics while arguing that research supports their position. Meanwhile, a large group of scientific minded individuals, without the resources of the pharmaceutical industry to promote their position, are doing their best to inform the public of a completely different set of conclusions. To move this disagreement in a positive direction, every now and then I take a look at the most current research.

For example (see HERE), a few years ago I reported on a study that suggested that:

Children and adolescents who take medication for attention-deficit hyperactivity disorder (ADHD) show decreased bone density, according to a large cross-sectional study that appeared in the Journal of Pediatric Orthopaedics.

More recently, I reported on a study that provided the latest replication of other studies indicating that ADHD drug treatment provides no lasting benefits for students classified as having ADHD on academic achievement and social functioning. After the drugs’ short-term stimulant boost, tolerance to the drugs occurs and any perceived benefits wane. The illusion that the drug continues to be helpful even after tolerance to the drugs occurs when people try to get off the drugs. The uncomfortable withdrawal effects they begin to experience lead to mistakenly thinking that they perform much better when taking the drug. It takes time for the body to be weaned off these drugs before they can begin to return to performing as well as they were doing while they were habitually taking the drug.

Although the drugged ADHD students didn’t do any better by the time they graduated high school than the non-drugged ADHD diagnosed students, many endured uncomfortable drug side effects, such as sleep problems, headaches, stomach aches, and feelings of depression each evening when the drug wore off.

Thousands of dollars are consumed on purchasing the drugs that achieved some modest short term gains but have no lasting positive effects.

Today, we take a look at a new study that is even more concerning. Medical doctors are hired to improve their patients’ health. The earlier decreased bone marrow study raises concerns about this. The various negative side effects raises additional concerns. But this latest study really raises a red flag.

Published November 22, 2023, in the Journal of the American Medical Association: Psychiatry, is titled “Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases.” Following subjects for up to 14 years, the study concluded:

In this case-control study of 278,027 individuals in Sweden aged 6 to 64 years who had an incident ADHD diagnosis or ADHD medication dispensation, longer cumulative duration of ADHD medication use was associated with an increased risk of CVD [cardiovascular disease], particularly hypertension and arterial disease, compared with nonuse.

The study looked at all ADHD medications approved in Sweden during the study period, including stimulants (methylphenidate, also known as Ritalin) amphetamine (also known as Adderall), dexamphetamine, and lisdexamfetamine, as well as non-stimulants. Throughout the entire follow-up, each 1-year increase in the use of ADHD medication was associated with a 4% increased risk of CVD. Similar results were observed when the researchers examined children or youth and adults separately. Results from the study suggest that the CVD risk associated with ADHD medication is approximately 23% higher for those on ADHD medication for more than five years compared with nonuse. This association between cumulative duration of ADHD medication use and CVD was similar in females and males. The study’s conclusion states:

The results of this population-based case-control study with a longitudinal follow-up of 14 years suggested that long-term use of ADHD medication was associated with an increased risk of CVD, especially hypertension and arterial disease, and the risk was higher for stimulant medications. These findings highlight the importance of carefully weighing potential benefits and risks when making treatment decisions on long-term ADHD medication use.

If Not Drugs, Then What

I discussed this topic extensively in another post (see HERE).  For now, I’ll just quickly summarize some of my favorite suggestions.

Search the internet with the following search terms–“ADHD without drugs.” If you do so, you will find many suggestions on how to address your concerns.  healthymeditationA daily running program and meditation are just a couple of excellent ideas that I found quickly in a recent search of this sort.

Many of the suggestions indicate that they have research support demonstrating that they are effective (see for example the article titled “Easing ADHD without Meds“). What I particularly like about having parents search the internet in this way is that they get to select from a wide range of ideas, the ones that make the most sense to them. Moreover, there are always new ideas coming out, and these types of internet searches are regularly updated.

In a school setting, students classified as having ADHD qualify for an Individual Education Plan (IEP). Getting an extra period of recess time each day on their IEP can dramatically improve their behavior. Supporting this, according to one study, levels of inappropriate behavior were consistently higher on days when ADHD labeled students did not have recess, compared with days when they did have recess. Results also showed that the level of inappropriate behavior for all participants progressively increased over time on days when they did not have recess. However, this progressive increase did not occur on days when the participants had recess.

I also recommend going to the library to get a copy of The Kazdin Method for Parenting the Defiant Child by Alan Kazdin.  Dr. Kazdin is director of the Yale Parenting Center and Conduct Clinic and is a former president of the American Psychological Association. His approach has been well tested in solid research programs with impressive results.

Another suggestion involves asking your child’s teacher to provide you, each week, a list of the main topics that will be covered in class the following week. Then view at home with your child a lesson on each topic on the Kahn Academy website.

Kahn AcademyThis website is a resource that provides free lessons on all the topics that teachers teach in school. By having your child review each lesson before hearing it for the first time from the teacher, when the teacher actually presents the lesson in school, your child will now be at least somewhat familiar with the topic. This is called “priming” and it has been demonstrated to increase the interest level for learners and increase the likeliness that the topic will end up being mastered.  Moreover, once you show your child how the Kahn Academy website works, your child, before each test, can go back to the lesson and make sure he or she has really mastered it.

If you do not have the time to do this with your child, see what you can do to get someone at least four years older than your child to carry out this activity. You may have to pay a young teenager a little.

This approach leads to real learning. Once your child starts to make better academic progress in school, he or she will feel better about school in general.

OK, there are some thoughts on avoiding an unhealthy approach to dealing with the concerns that arise when a child is labeled ADHD. Feel free to express in the comment section below any disagreements with anything I’ve written or agreement, and if you have some suggestions for non-drug approaches, please let us know about this.

My Best,
Jeff

Categories
ADHD medication American Psychiatric Association conflict resolution MindFreedom International psychiatric drugs psychiatric medications psychiatry Ritalin

Psychiatric Drugs: Wonderful Revolution or Ongoing Catastrophe?

Welcome to From Insults to Respect.

A while ago, as I began to think about what topic to write about for my next post, I received an email from Mindfreedom International (MI). It brought attention to a demonstration it was planning. As MI expressed it in part:

A mock funeral mourning those lost to psychiatry or who have had their spirits broken and struggle to survive is to be held as protesters deliver a public message to psychiatrists at the annual meeting of the American Psychiatric Association on Sunday, May 6, 2018. “First, Do No Harm” is the message that protesters hope will go viral and get people to think twice before getting involved with psychiatry.

Our coalition brings attention to the harm that psychiatry has caused for many people in the mental health system, psychiatric survivors, people of color, people with psychiatric histories, and people experiencing other forms of structural oppression. Uninformed or court-ordered psychiatric drugging; chemical and mechanical restraints, solitary confinement; forced and uninformed shock treatments….have caused irreversible damage to the minds, bodies, souls, and lives of people who voluntarily trusted their doctors or were brought to court to comply with their prescriptions over their objection….We will mourn the deaths and the ongoing forced treatment of our brothers and sisters.

Is there a way to move MI’s various conflicts with the psychiatric organization forward in a manner that leads to a more respectful relationship between the two?

My Views About Psychiatric Drugs

I became interested in the conflict about the use of psychiatric drugs very early in my career as a psychologist. I began to discuss the issues with psychiatrists as well as those who objected to this form of treatment. A broad outline of what I heard follows:

Advocates for the use of these drugs make the following claims: These drugs reduce emotional pain, correct abnormal brain patterns, and restore normal mental function. When used judiciously, they reduce hospitalization and may quickly alleviate symptoms of serious mental disorders such as depression and bipolar illness. Going off medication results in disruptive lives and devastating personal loss. Careers, relationships, financial troubles, and even life itself are all placed at grave risks without proper psychiatric medication management. 

In contrast, critics of psychiatric drugs have made the following counter claims: The use of psychiatric drugs has unleashed the worst medically induced disaster in history. They have caused millions of people to become addicted to them, suffering debilitating, life threatening side effects. Rather than promoting mental health, these drugs are being used to promote social control and conformity. Reduction in hospitalization, moreover, occurred not because of the use of these drugs, but because of a deinstitutionalization policy that became known as “dumping.” Problems now being handled with psychiatric drugs can be more effectively, safely, and humanely handled with a variety of social support systems, counseling, mindfulness, healthy diet, and physical exercise techniques.

As I heard these conflicting claims, I initially thought that psychiatrists had principles of science on their side. With my graduate training in research methods and statistics, I thought that by doing a thorough job finding out the scientific research that backs up the psychiatric drug supporters I could explain in an easy to understand language why psychiatric drugs are necessary. With such an explanation, perhaps the conflict would be resolved.

My Ritalin Research Analysis

I began with researching Ritalin because I was working in Rochester, NY’s school system. This was from 1974 to 1979. It was a time when drugs were just beginning to be prescribed more and more to treat students who had teachers dissatisfied with their activity level or ability to pay attention. I had witnessed a time when schools managed to deal with such problems without the use of this drug and life went on reasonably well. With the rise in its use, some thought it was a wonderful advancement, while others were expressing great discomfort at this new trend.

So, off I went to a medical library to learn the scientific merits of this new approach. A brief summary of what I found follows.

Supporting the use of Ritalin were short-term randomized controlled studies lasting less than 12 weeks. Both inattentiveness-impulsivity and activity level were reduced, as assessed by parent and teacher rating scales, direct observations in natural settings, and various laboratory tests.

Not all of the findings were supportive. At the time I initially did my research, there was only one study that looked at the long-term results of Ritalin use. It compared children placed on methylphenidate, the generic version of Ritalin, with those who received no treatment. The children in the two groups were matched with respect to age, IQ, socioeconomic class and sex. After 3 to 5 years, no statistically significant differences were found between the two groups on the following outcome measures: emotion maladjustment, delinquency, Wechsler Intelligence Scale for Children, Bender gestalt visual-motor test, and academic performance.

In addition to this, I found many studies documenting a number of common adverse effects of treatment, such as headaches, insomnia, anorexia, stomach pain, irritability, and weight loss. Suppression of the normal rate of growth was just beginning to be reported. The sudden development of a tic disorder that sometimes did not go away when treatment stopped was viewed as a rare occurrence, but troubling nevertheless. Other serious rare adverse events had been observed including some involving heart functioning such as angina and cardiac arrhythmias. Perhaps most troubling of all was the recognition that the safety of long term use of Ritalin had not been established despite many students being treated for years.

To make sure that my analysis of the available scientific evidence was complete, I sent a Freedom of Information Request to the Food and Drug Administration for the documents that it used to approve the use of Ritalin with children as a treatment for attention and activity problems. I soon received a fairly large packet of information, and upon reviewing its contents I became convinced that I had not overlooked anything of scientific merit.

In the end, I discovered that although the approval process of the FDA had in its documents the available scientific evidence in making its decision to approve Ritalin, the reviewers’ decision nevertheless relied more on their personal values. It seemed to me, and it still does, that different people looking over the same scientific evidence could, depending on their values, come to completely different conclusions about whether or not the drug should be approved.

For me, personally, with the full awareness of the scientific evidence, I would have voted against approval of the drug. Relevant to me was that after thousands of dollars had been spent by the parents of the child or their insurance company, there was no lasting positive effects, while treated children were suffering side effects. The additional facts, especially the one that indicated long term safety had not been established, seemed to me to make non-approval the obvious choice. And yet, according to the value judgments of those who sat on the FDA approval board, they ended up supporting approval.

What I Found Afterwards

Since then, more research has come out regarding the drugs used to deal with ADHD. It further supports the conclusion that there are no long term benefits from using these types of drugs. Moreover, additional harm from their use has been identified.

After what I learned about the ADHD drug treatments, my efforts to find out about psychiatric drugs expanded.

Dr. Ross J. Baldessarini

As time went on, I took a psychopharmacology course taught by Harvard professor Dr. Ross J. Baldessarini; did additional research to get the latest updates, not only on Ritalin, but on other psychiatric drug treatments; and participated in six debates on this subject.

I’ve come to the conclusion that as with Ritalin, when highly intelligent people become familiar with the scientific evidence, they still draw completely different conclusions from one another about whether or not it is morally okay to use the approved drugs as a treatment. The decision is not solely made on scientific evidence. Moreover, I’ve seen evidence that there are far safer non-drug alternatives.

Since I did my original research on Ritalin, I also learned something crucial about the reliability of the relevant research findings. Initially, I assumed the scientific studies were carried out in a manner that I could have confidence in. Since then, I’ve begun to seriously question this.

Many experts have written about the reliability of the research. For example, Marcia Angell, M.D., is a former editor in chief of The New England Journal of Medicine, and now is a member of Harvard’s Medical School. In her insightful book, The Truth About the Drug Companies: How They Deceive Us and What to Do About It, she writes, “Is there some way companies can rig clinical trials to make their drugs look better than they are? Unfortunately, the answer is yes. Trials can be rigged in a dozen ways, and it happens all the time” (p. 95).

Conclusion

And so, even if we believe that the available research is accurate, it just so happens that an examination of it leads to very different moral conclusions by very intelligent people about the wisdom of using these drugs. The pharmaceutical industry’s influences on the body of research about the safety and effectiveness of these drugs make these types of conclusions ever more questionable.

For those interested in following the peer reviewed scientific research about the effectiveness and safety of these drugs, I highly recommend the Mad In America website. It describes the latest research in non-technical language while providing the links to all of the actual research articles so readers, if they so choose, can read them for themselves.

Members of MI have seen first hand people who have died and who have suffered terribly as a result of their involvement with the psychiatric profession. At the same time, psychiatrists also well know that there are many incidences of tragic outcomes due to their treatments, but they have come to believe that overall the benefits of their treatments far outweigh all of those tragedies. And the enormous financial benefits that come with being a psychiatrist are very likely to influence their views.

Civil rights activists worked for generations to make some progress in achieving their goals. Among the most successful of these advocates was Martin Luther King, Jr. When advocating for civil rights, he avoided throwing insults at those who resisted the changes he was after. Instead, he focussed on painting his dream in beautiful, hopeful phrases and demonstrating in nonviolent, but impossible to ignore, peaceful resistance.

In a country where many of our current politicians have taken to insulting anyone who disagrees with them, King’s approach may seem out of style. As for me, I personally think King’s approach is as timeless as stars twinkling in the heavens.

 

Categories
ADHD ADHD medication ADHD Research conflict resolution

ADHD: The Latest 2017 Research

Currently, in many countries a wide variety of children are being classified as having ADHD and placed on a regimen of consuming psychiatric drugs. Supporters of this trend often cast a disrespectful eye toward their critics while arguing that scientific research supports their position. Meanwhile, equally scientific minded individuals who have looked at the same research come up with a completely different set of conclusions. So, about once a year I take a look at the most current research to see if I can throw some light on this topic.

Last year, for example (see HERE), I reported on a study that suggested that:

Children and adolescents who take medication for attention-deficit hyperactivity disorder (ADHD) show decreased bone density, according to a large cross-sectional study that appeared in the Journal of Pediatric Orthopaedics.

I also reported last year on another study that provided the latest replication of other studies indicating that drug treatment provides no lasting benefits for students classified as having ADHD.

Factors looked at were academic achievement and social functioning. Although the medicated ADHD students didn’t do any better or worse on these measures then the unmedicated ADHD students, they did endure many uncomfortable side effects while they were on the ADHD drugs, such as sleep problems, headaches, stomach aches, and feelings of depression each evening when the drug wore off. Thousands of dollars per child were consumed on purchasing the medications that achieved some modest short term gains but had no lasting positive effects.

How about this year? Are there any new studies that throw light on the ADHD controversy?

The Latest Study

The April 2017 issue of Lancet Psychiatry contains a write-up of a study that looked at the largest data set to date to see if people who have been labelled as having ADHD had some difference in certain regions of their brains than people who were not labelled (the control group). The sample comprised 1713 participants labelled as having ADHD and 1529 controls from 23 sites with a median age of 14 years (range 4–63 years).

Of the 8 areas of the brain that they looked at using MRI scans, 6 were statistically smaller for the group of ADHD labelled people when compared to the control group, but this statistical difference was only found for the group of children younger than 15. When the study looked at these regions of the brains of adults, there were no statistically significant differences.

The authors claimed that their analysis supports the theory that ADHD is due to a delay in the brain maturing. Finally, they concluded that their study contained important messages for clinicians: “The data from our highly powered analysis confirm that patients with ADHD do have altered brains and therefore that ADHD is a disorder of the brain. This message is clear for clinicians to convey to parents and patients, which can help to reduce the stigma that ADHD is just a label for difficult children and caused by incompetent parenting. We hope this work will contribute to a better understanding of ADHD in the general public” (p. 7).   

Media Coverage of the Latest Study

Even before the study was published in the April 2017 issue, media outlets rushed to cover the story. Here is a sampling of headlines:

Critical Analysis

Dr. Corrigan
Robert Whitaker

Shortly after the publication of this study, two people with impressive scientific credentials, Michael W. Corrigan, Ed.D. and Robert Whitaker, thoroughly analyzed it, and concluded that the study is very misleading and they are calling for it to be retracted. Their entire analysis, which I highly recommend, is available for free HERE. For my readers, I will summarize a few of its key points.

The authors refute the study’s conclusion that it found that people labelled as having ADHD have smaller brain volumes. Thus they state:

“In this study, the authors pooled together MRI brain-scan data for the 3,242 participants in the study (which had been collected and archived at the 23 sites), and then calculated, for each cohort, mean intracranial volumes and mean volumes of specific brain regions. They reported the differences for each of these comparisons and the “effect size” of the differences. This is the critical aspect of the results to consider and understand: effect sizes reveal the true strength of the findings and how much overlap there is between the individual brain volumes in both groups, and thus establish the likelihood that an individual in the ADHD group has a smaller brain volume than an individual in the control group.

The biggest effect size that was found was .19. This was for differences in the mean volume of a region known as the accumbens for ADHD labelled children under 15 years of age. An effect size of 3, which is the largest effect size one can obtain using this type of statistic, would have suggested that pretty much all of the children in the study that were labelled as having ADHD had a distinctly smaller volume in that region than controls. An effect size of 2 would have suggested a distinctly weaker relationship and that some of the children in the ADHD group did not have smaller volumes than the control group, some in the ADHD group had larger volumes than the control group, and some of the control group had smaller than average volumes in that region and yet showed no signs of ADHD. An effect size of 1 would have indicated even a weaker relationship. The effect size of .19 is less than a fifth the size of 1, that is, about a small an effect size as you can imagine. (To learn more about what an effect size is, access this article by Robert Coe: It’s the effect size, stupid.) The critique summarizes this issue as follows:

“In short, if you just flipped a coin to guess which of the two cohorts the child belonged to, your odds of being right would be nearly the same. The diagnostic value of an MRI brain scan, based on the findings in this study, would be of little more predictive value than the toss of a coin.”

Perhaps the best way to understand this is to look at the individual site data. Thus, the study’s authors reported that the “volumes of the accumbens, amygdala, caudate, hippocampus, putamen, and intracranial volume were smaller in individuals with ADHD compared with controls in the mega-analysis” (p. 1). If this is true, then smaller brain volumes should show up in the data from most, if not all, of the 21 sites that had a control group. But that was not the case.

Here are summaries of individual site results:

  • Mean accumbens volumes: At 4 sites, the volume for the ADHD cohort was actually larger than for the control, and at another 6 sites, the mean volumes were basically of equal size.
  • Mean amygdala volumes: At 5 sites, the mean volume for the ADHD cohort was larger than for the controls, and of equal size at 4 others.
  • Mean caudate volumes: At 5 sites, the mean volume for the ADHD cohort was larger than for the controls, and of equal size at 2 others
  • Mean hippocampus volumes: At 7 sites, the volume for the ADHD cohort was larger than for the controls, and of equal size at 4 others.
  • Mean putamen volumes: At 5 sites, the volume for the ADHD cohort was larger than for the controls, and of equal size at 1 other.
  • Mean intracranial volumes: At 5 sites, the volume for the ADHD cohort was larger than for the controls.

“The problem here is obvious,” says the writers of this critique. “If the authors are claiming that smaller brain regions are a defining ‘abnormality’ of ADHD, then such differences should be consistently found in mean volumes of ADHD cohorts at all sites. The fact that there was such variation in mean volume data is one more reason to see the authors’ conclusions—that smaller brain volumes are a defining characteristic of ADHD—as unsupported by the data.”

The critique goes on to mention a number of other serious problems with this study. For example, in a scientific study we look for possible sources of bias. The critique correctly points out that this study was written by an authors’ group that included many who had close ties to pharmaceutical companies that sell ADHD medications. We can also surmise that some, if not all, of the authors who do not currently have ties to these pharmaceutical companies may hope to land in the future financially rewarding speaking fees sponsored by these companies.

There are many other serious weaknesses with this study that the critique points out, but since it is readily available for free, I’ll end my summary here. My own conclusion is this. The study’s results are highly questionable. Particularly troubling is the suggestion by the study’s authors that their findings will help to reduce stigma. How in the world does telling people that ADHD people have smaller brains help to reduce stigma for that group of people? Moreover, even if we found enough evidence to conclude that there are some differences in the brains of people being labelled ADHD, this would still not lead us to conclude they have a brain disorder. A difference is not automatically a disorder. Having people with different brains can be a wonderful thing. For example, it can mean that some people will prefer to work sitting all day, while others prefer to do work requiring lots of activity. We need both types of people, and other types as well, to enrich our lives.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on. This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence. To begin at the very first post you can click HERE.

Categories
ADHD ADHD medication conflict resolution Ritalin

Research Update On ADHD Drug Treatments

In earlier posts, I have reviewed the research on ADHD drug treatments. The findings have led me to the conclusion that medicalizing the behavior pattern that medical doctors refer to as symptoms of ADHD causes far more harm than good. New readers can check out my earlier posts on this subject HERE, HERE, HERE, HERE, and HERE.

boy-with-stomach-painBriefly, the main side effects of the commonly prescribed drugs for so called “ADHD” are:

  • Sleep problems
  • Decreased appetite
  • Delayed growth
  • Headaches and stomachaches
  • Rebound (irritability when the medication wears off)
  • Tics
  • Moodiness and irritability

Fears have been raised about potential long-term effects of stimulant drugs on the heart and on the child’s developing brain. But the available data on these outcomes is limited, so the true effects are still unknown but legitimately worrisome.

On June 15, 2009, the FDA put out the following warning: “The FDA reported on a study reviewing 564 healthy children taking stimulants who died suddenly. They notified the public that there might be an association between the use of stimulant medications and sudden death in healthy children.”

school workIn my earlier blog posts, I also reviewed research studies that indicate that almost immediately after taking these types of drugs, many children will complete more academic work and get more of the items correct. Parents also tend to report behavioral improvements. But these effects begin to wane. According to the best available evidence, by a little over a year, any perceived improvement, when objectively measured, had completely disappeared. The available studies indicate no lasting benefits for those who use them in terms of academic achievement, social outcomes, and high school graduation rates. In the end, thousands of dollars have been spent and the drug treated children, having suffered the various side-effects and been subjected to serious risks are no better off than children who had similar behavior challenges but did not take any of the ADHD drugs.

So, after I carefully weighed all of this information, I concluded that children would be far better off if we rejected the ADHD medical model. Since my last post on this subject was published, three new relevant research studies have been carried out. Let’s take a look at them.

First Study

On March 3, 2016, News4Jax, out of Jacksonville, Florida reported that “ADHD medications associated with diminished bone health in kids.” Here’s what they had to say:

“ORLANDO, Fla. – Children and adolescents who take medication for attention-deficit hyperactivity disorder (ADHD) show decreased bone density, according to a large cross-sectional study presented today at the 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons .

“This is an important step in understanding a medication class, that is used with increasing frequency, and its effect on children who are at a critical time for building their bones,” said senior study author Jessica Rivera, MD, an orthopaedic surgeon with the U.S. Army Institute of Surgical Research.”

This study recently appeared in the online edition of the Journal of Pediatric Orthopaedics.

Second Study:

On March 12, 2016, the New York Times published an article titled, “Is It Really A.D.H.D. or Just Immaturity?” There we learn of a study published in The Journal of Pediatrics indicating that the youngest students in a classroom are more likely to be given a diagnosis of attention deficit hyperactivity disorder than the oldest.

chinese students“Researchers in Taiwan looked at data from 378,881 children ages 4 to 17 and found that students born in August, the cut-off month for school entry in that country, were more likely to be given diagnoses of A.D.H.D. than students born in September. The children born in September would have missed the previous year’s cut-off date for school entry, and thus had nearly a full extra year to mature before entering school.”

The authors of the study concluded, “Our findings emphasize the importance of considering the age of a child within a grade when diagnosing A.D.H.D. and prescribing medication for treating A.D.H.D.”

These findings support similar results of an earlier study in the United States, which found that roughly 8.4 percent of children born in the month before their state’s cutoff date for kindergarten eligibility are given A.D.H.D. diagnoses, compared to 5.1 percent of children born in the month immediately afterward.

Third Study:

school work bOn March 13, 2016, The Sydney Morning Herald published the latest article describing a study that provides further evidence that drug treatment provides no lasting benefits for students classified as having ADHD. The study was funded by the National Health and Medical Research Council in Australia and carried out by the Murdoch Childrens’ Research Institute. It has been following 178 children with ADHD for three years to identify what factors make a difference to the development of children with the disorder. One of the chief investigators of the project is pediatrician Daryl Efron. He reported that,

“The 13 per cent of children in the study who were taking medication such as Ritalin to treat their ADHD were doing no better or worse than their unmedicated peers at age 10. Medication doesn’t alter the long-term outcomes of kids [with ADHD].”

Analysis

The kind of attention that you have to use in school is difficult for many people. This certainly was true for me, and I was not one of the youngest students in my grade. The teachers had us sitting way too long, and some subjects, such as spelling and grammar, were not as interesting to me as it was for some of the other students. And so I became awfully restless.

basketball-playersIn my opinion, I did not have a medical illness. Out on the streets of Brooklyn, I was as healthy as a horse as I got into handball, basketball, and stickball games for hours and hours during my free time. Nevertheless, I am certain that if my parents had taken me to a doctor in this modern world of ours, I very likely would have been given an ADHD label and placed on one of the ADHD drugs.

Even if the drugs actually did lead to some positive lasting outcomes, their potential harm in terms of physical problems and thousands of dollars of wasted money should be weighed against these positives. But the research has repeatedly demonstrated that there are no lasting benefits. And so, I’m continuing to urge parents to remain cautious as they become bombarded by the drug treatment options they surely will be facing in our pharmaceutical dominant society.

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Some people will enjoy reading this blog by beginning with the first post and then moving forward to the next more recent one; then to the next one; and so on.  This permits readers to catch up on some ideas that were presented earlier and to move through all of the ideas in a systematic fashion to develop their emotional intelligence.  To begin at the very first post you can click HERE.